HYPERSENSITIVITY TO MOSQUITO BITES

By Gary M. White, MD


Hypersensitivity to mosquito bites (HMB) goes beyond the usual itchy wheal at the bite site. The patient with HMB may experience bulla, ulceration, necrosis and/or scarring at the bite site and systemic symptoms such as high fever, lymphadenopathy, hepatosplenomegaly, hepatic dysfunction, hematuria, and proteinuria. Natural killer cells proliferate in abnormally high amounts in the skin lesions and blood in patients with HMB. The finding of clonal Epstein-Barr virus (EBV) DNA-positive natural killer cells suggests this is an EBV-associated lymphoproliferative disease. The majority of patients are from Japan or Korea and less than 20 years of age.

Of note, hydroa vacciniforme also falls within the Epstein-Barr virus (EBV)-associated T/natural-killer lymphoproliferative disorders.

References

An 18-year-old Korean boy presented with an erythematous 4 cm nodule on his left lower leg after a mosquito bite. The lesion then evolved into a necrotic and hemorrhagic ulcer. Regional lymphadenopathy was observed. Biopsy of the skin lesion revealed anaplastic large cell lymphoma. Korean J Fam Med. 2015 Jan;36(1):35-41

A 6-yr-old Korean boy presented with severe reactions in response to mosquito bites. Specifically, he would develop erythematous swellings and bulla formation at the bite site with fever, regional lymphadenopathy and/or phlebitis. The skin lesions evolved into necrotic ulcers and healed with residual scarring. J Korean Med Sci. 2013 Jan; 28(1): 164–166

RegionalDerm

Homepage | FAQs | Use of Images | Contact Dr. White


It is not the intention of RegionalDerm.com to provide specific medical advice, diagnosis or treatment. RegionalDerm.com only intends to provide users with information regarding various medical conditions for educational purposes and will not provide specific medical advice. Information on RegionalDerm.com is not intended as a substitute for seeking medical treatment and you should always seek the advice of a qualified healthcare provider for diagnosis and for answers to your individual questions. Information contained on RegionalDerm.com should never cause you to disregard professional medical advice or delay seeking treatment. If you live in the United States and believe you are having a medical emergency call 911 immediately.