GRANULOMATOUS SLACK SKIN

By Gary M. White, MD

Granulomatous slack skin Courtesy of James Steger, MD.


Granulomatous slack skin is a rare variant of cutaneous T-cell lymphoma (CTCL) in which there is thickening and folding of the skin often of the axilla but also the groin. Patients are at high risk (up to 50% in reported cases) for secondary lymphoproliferative neoplasms, most commonly Hodgkin's disease and non-Hodgkin's lymphoma, but also acute myeloid leukemia and Langerhans cell histiocytosis.

Clinical

Red, infiltrated plaques which may have epidermal atrophy and fine scale may develop initially. Later, these areas become wrinkled and pendulous. Large hanging, bag-like folds may be seen. The axilla, groin, and abdomen are most commonly affected. The majority of patients are men.

Treatment

No treatment is consistently effective. Treatments have included topical steroids, PUVA, radiotherapy, imuran, chlorambucil, surgical debulking, and topical nitrogen mustard. In one patient, acute exacerbation was successfully treated with system recombinant interferon-gamma. Surgical excision is usually accompanied by recurrence within months.

References

Granulomatous slack skin. Dermatology Online Journal 12 (7): 20
JAAD February 2014 Volume 70, Issue 2, Pages 205.e1–205.e16

RegionalDerm

Home | FAQs | Use of Images | Privacy Policy | Contact


It is not the intention of RegionalDerm.com to provide specific medical advice, diagnosis or treatment. RegionalDerm.com only intends to provide users with information regarding various medical conditions for educational purposes and will not provide specific medical advice. Information on RegionalDerm.com is not intended as a substitute for seeking medical treatment and you should always seek the advice of a qualified healthcare provider for diagnosis and for answers to your individual questions. Information contained on RegionalDerm.com should never cause you to disregard professional medical advice or delay seeking treatment. If you live in the United States and believe you are having a medical emergency call 911 immediately.