GRANULAR PARAKERATOSIS

By Gary M. White, MD


Axillary Granular Parakeratosis


Granular Parakeratosis (GP) is a benign build up of keratin with hyperkeratosis, compact parakeratosis, and reten-tion of basophilic keratohyaline granules histologically. Some have postulated that this disease is caused by a defect in profilaggrin degradation in the granular layer.

Clinical

Unilateral or bilateral axillary, pigmented, erythematous, or keratotic papules and plaques are characteristic. The axilla is the most usual site, but lesions of the groin, axillae, inframammary folds, neck and abdominal folds may occur. Pruritus is typical. The lesions may resemble Hailey-Hailey disease.

Treatment

No treatment is needed. Topical steroids and antifungal agents used in combination have been curative in some cases. One patient required oral isotretinoin for clearing.

References

Typical lesions in the axilla. Our Dermatology Online

Here, on the neck of a healthy baby. Our Dermatology Online

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