GRAHAM-LITTLE PICCARDI LASSUEUR SYNDROME

By Gary M. White, MD


Graham-Little Piccardi Lassueur Syndrome is a rare variant of lichen planopilaris characterized by the triad of

It is four times more common in women than men and patients are typically 30-70 years of age.

Treatment

Regrowing hair that is already lost is usually not possible in scarring alopecias. See lichen planopilaris for halting the progression. Therapy for the follicular papules can start with a topical steroid or calcineurin inhibitor (tacrolimus, pimecrolimus) for any inflammation and a keratolytic, e.g., urea or a topical retinoid for the abnormal keratinization. An oral retinoid may be beneficial if the process is mainly abnormal keratinization of the follicle. To suppress any inflammatory component, UVB therapy, hydroxychloroquine, and cyclosporin may be considered.

References

Graham-Little Piccardi Lassueur syndrome: An unusual variant of follicular lichen planus. Int J Trichol 2011;3:28-30

Dermatology Online Journal, 21(7) (in Portuguese)

Dermatology Online Journal, 21(6)

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