By Gary M. White, MD

Gloves and socks syndrome

Gloves and socks syndrome is an unusual exanthem that can result from a variety of viral infections, but most commonly by Parvovirus B19 (also Epstein-Barr virus, measles, rubella, human herpes virus-6, cytomegalovirus, or Coxsackie B6). Lymphadenopathy, leukopenia, fever and oral erythema, petechiae, vesicles, or erosions may occur. Parvovirus B19 DNA has been recovered from the skin by polymerase chain reaction. The condition occurs in both adults and children.


Confluent erythema of the palms and soles that stops at the wrists and ankle is characteristic. Significant purpura often occurs. Less commonly reported findings include dysuria with vulvar edema and erythema and a unilateral petechial rash on the breast.


No specific therapy is needed as the rash will resolve spontaneously.

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Gloves and socks syndrome Gloves and socks syndrome

Gloves and socks syndrome


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