By Gary M. White, MD

Gianotti-Crosti syndrome

Papular acrodermatitis of childhood (PAC), also known as Gianotti-Crosti syndrome, is a self-limited disorder with acute onset generalized lymphadenopathy and a symmetric erythematous papular and papulovesicular eruption of the face, neck, buttocks, and extremities, usually occurring in young children. This rash seems to result from an underlying viral infection, and has been noted to occur in association with molluscum, hepatitis B, varicella, coxsackie virus, CMV, enterovirus, hepatitis A, herpes simplex 1 virus and Epstein-Barr viruses.


The patient presents with symmetric, inflammatory red papules and plaques on the arms, legs, and cheeks. It tends to spare the trunk.


LFT's may be obtained but are usually normal. The rash will resolve within 4-6 weeks without sequelae.

Additional Pictures

An infant with PAC.
Gianotti-Crosti syndrome Gianotti-Crosti syndrome

A 5-year-old boy with 10 days of a rash prominent on the cheeks, knees and dorsal feet.
Gianotti-Crosti syndrome Gianotti-Crosti syndrome

Koebnerization may occur.
Gianotti-Crosti syndrome


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