GENERALIZED ERUPTIVE HISTIOCYTOSIS
By Gary M. White, MD
Generalize eruptive histiocytosis (GEH) is a rare non-Langerhans cell histiocytosis that presents with multiple nodules.
- Most cases of GEH are benign, but there are a few reports of association with hematologic malignancies, e.g. acute monocytic leukemia or chronic myelomonocytic leukemia.
The typical patient presents with multiple asymptomatic red to brown macules and papulonodules on the trunk and extremities.
Since the disease may remit spontaneously, observation may be done. Other approaches include the carbon dioxide laser, cryotherapy, PUVA, hydroxychloroquine, oral isotretinoin and systemic steroids.
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