By Gary M. White, MD
Galli–Galli disease (GGD) is a rare autosomal dominant condition characterized by reticulate pigmentation of the flexures.
- It is clinically identical to Dowling–Degos disease (DDD) but shows acantholysis histologically.
- GGD and DDD are allelic variants, with mutation of keratin 5 (KRT5 gene).
Reticulate hyperpigmentation of the flexures and reddish-brown hyperkeratotic, scaly papules of the trunk and extremities are characteristic. Onset of the pigmentary changes may occur in the teens or twenties.
No treatment has been reliably effective. The erbium:YAG laser was reported effective in one case [AD 2011;147;317].
The first report of KRT5 mutation underlying acantholytic Dowling-Degos disease with mottled hypopigmentation in an Indian family. Indian J Dermatol 2014;59:476-80
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