By Gary M. White, MD
Gadolinium-Associated Plaques (GAP) are erythematous plaques 0.5-2.5 cm in diameter in a patient given gadolinium.
- GAP are generally associated with nephrogenic systemic fibrosis.
- Histopathology shows sclerotic bodies which are eosinophilic, round or oval laminated collagen globules containing scattered solitary cells with plump nuclei as if in lacunae.
- Mass spectrometry has shown dermal deposition of gadolinium in these sclerotic bodies [JAMA Derm 2018;154;105].
JAMA Derm 2015;151;316.
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