By Gary M. White, MD

The drug Foscarnet is an antiviral agent used to treat CMV and acyclovir-resistant herpes. It has been reported to cause painful penile and vulvar ulcerations [Cutis 2017;99;14].


It has been proposed that foscarnet which may be excreted unchanged in the urine may cause a local irritant reaction causing ulceration. Thus, keeping well hydrated to avoid a concentrated urine and washing the genitalia after urination may prevent ulceration. Otherwise, the medication may be stopped.


  1. JAAD 1992;27;124
  2. IJD 1993;32;526 (CP)

Genitourinary Medicinem 1992;68;182


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