By Gary M. White, MD

Flegel's disease (FD) is a rare skin condition characterized by red/brown hyperkeratotic papules on the dorsa of the feet and legs.


Also known as hyperkeratosis lenticularis perstans, this disease is characterized by red/brown hyperkeratotic papules often with an erythematous halo on the dorsa of the feet and legs. More extensive involvement of the trunk and neck is rarely reported [J Dermatol Case Rep. 2012 Sep 28; 6(3): 93–95].


Treatment is not necessary. However, topical 5-FU 5% cream has been said to be the most reliably effective. Other considerations are oral or topical retinoids, calcipotriol, PUVA, dermabrasion and salicylic acid.


JAAD 2015;73; 346–348


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