By Gary M. White, MD
Flegel's disease (FD) is a rare skin condition characterized by red/brown hyperkeratotic papules on the dorsa of the feet and legs.
- An autosomal dominant inheritance is proposed and onset is usually in adulthood.
Also known as hyperkeratosis lenticularis perstans, this disease is characterized by red/brown hyperkeratotic papules often with an erythematous halo on the dorsa of the feet and legs. More extensive involvement of the trunk and neck is rarely reported [J Dermatol Case Rep. 2012 Sep 28; 6(3): 93–95].
Treatment is not necessary. However, topical 5-FU 5% cream has been said to be the most reliably effective. Other considerations are oral or topical retinoids, calcipotriol, PUVA, dermabrasion and salicylic acid.
JAAD 2015;73; 346–348
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