By Gary M. White, MD

The eosinophilic ulcer is a benign, self-healing ulcer of the tongue of unknown cause. Trauma has been suspected. Histologic examination shows an ulceration with eosinophils prominent within the inflammatory infiltrate.


The classic history is a rapidly developing ulcer with raise, indurated borders that forms on the posterior aspect of the tongue. It then spontaneously resolves in a few weeks.


The differential diagnoses include trauma-induced, infection, autoimmune diseases and rarely malignancies.


Acute ulcerations may be observed for spontaneous healing. Lesions that persist should be biopsied. If the patient is HIV-positive or otherwise immune-compromised infections such as Herpes, Candida and Histoplasmosis may be considered. Biopsy, culture, and/or presumptive treatment may be considered depending upon the clinical situation.

Other therapies that have been used include antibiotics, topical, intralesional and/or systemic corticosteroids, curettage, cryosurgery and surgical excision.


Lesion on the tongue with no history of trauma. Ann Stomatol (Roma). 2012 Jan-Mar; 3(1): 11–13.


Homepage | FAQs | Use of Images | Contact Dr. White

It is not the intention of RegionalDerm.com to provide specific medical advice, diagnosis or treatment. RegionalDerm.com only intends to provide users with information regarding various medical conditions for educational purposes and will not provide specific medical advice. Information on RegionalDerm.com is not intended as a substitute for seeking medical treatment and you should always seek the advice of a qualified healthcare provider for diagnosis and for answers to your individual questions. Information contained on RegionalDerm.com should never cause you to disregard professional medical advice or delay seeking treatment. If you live in the United States and believe you are having a medical emergency call 911 immediately.