By Gary M. White, MD

eosinophilia myalgia White papules in eosinophilia myalgia

Skin lesions in eosinophilia myalgia include morphea-like sclerosis, urticarial and papular lesions and generalized sclerosis. Eosinophilia, myalgia, fever, weakness and fatigue are also typical. Tryptophan is and essential amino acid and a metabolic precursor of serotonin. It was purchased by many as an over the counter sleeping pill. During production, a di L-tryptophan molecule was formed which is thought to be the etiologic agent.


Consumption of tryptophan should of course be stopped. No single therapy is consistently effective. Prednisone (e.g. 20-100 mg/day) has been used. Patients tend to improve over time.


The death rate was 19% in one study from South Carolina (approximate 3 year period) [AIM 1996;156;973]. Survivors had morbidity from myalgia, arthralgia, weakness, rash, alopecia and sclerodermoid skin changes.


Homepage | FAQs | Contact Dr. White


Homepage | FAQs | Use of Images | Contact Dr. White

It is not the intention of RegionalDerm.com to provide specific medical advice, diagnosis or treatment. RegionalDerm.com only intends to provide users with information regarding various medical conditions for educational purposes and will not provide specific medical advice. Information on RegionalDerm.com is not intended as a substitute for seeking medical treatment and you should always seek the advice of a qualified healthcare provider for diagnosis and for answers to your individual questions. Information contained on RegionalDerm.com should never cause you to disregard professional medical advice or delay seeking treatment. If you live in the United States and believe you are having a medical emergency call 911 immediately.