By Gary M. White, MD
The eccrine spiradenoma (ES) is a benign adnexal tumor of sweat gland origin. Malignant transformation may rarely occur.
- ES usually occurs as a single lesion in patients aged 15–35 years.
- Multiple ES in a linear or zosteriform distribution have been reported, but are rare.
- Although the exact etiology of these lesions is unknown, spiradenomas appear to be caused by a defective tumor suppressor gene.
- ES may occur with other tumors such as cylindromas and trichoepithelioma as seen in Brooke-Spiegler syndrome.
- Historically ES has been thought of eccrine lineage, however recently, some believe it is of apocrine origin.
A solitary dermal, firm, flesh-colored or bluish papulonodule in a young adult is most characteristic. These lesions may be painful.
This is a benign lesion. It may be left alone (but the patient told of the very low risk of malignant change and if left, call any growth/change etc). Complete surgical excision is also appropriate.
Segmental eccrine spiradenoma. J Clin Aesthet Dermatol. 2011 Apr; 4(4): 38–44
Giant eccrine spiradenoma. Indian J Dermatol Venereol Leprol 2015;81:79-80
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