DYSCHROMATOSIS UNIVERSALIS HEREDITARIA

By Gary M. White, MD

Dyschromatosis universalis hereditaria (DUH) is characterized by generalized asymptomatic hypo- and hyperpigmented macules occurring all over the body and the patient is usually otherwise well.


Clinical

Dyschromatosis universalis hereditaria (DUH) is characterized by generalized asymptomatic hypo- and hyperpigmented macules occurring all over the body. Eighty percent of affected individuals develop dyschromia before age 6 and approximately 20 percent present at birth. The oral mucosa is usually spared. The palms and soles may rarely be involved. Although generally considered to be an asymptomatic condition, some cases have been associated with neurosensory hearing loss, learning difficulties, severe mental retardation, photosensitivity, insulin-dependent diabetes, and ocular abnormalities.

Treatment

No treatment is needed. The Q-switched alexandrite laser has been used to improve the appearance on the face [JAAD 2011;65;e61-e63].

References

Dermatology Online Journal 14(2)

Dermatology Online Journal 17(8)

Dermatology Online Journal 17(7)

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