By Gary M. White, MD
Cutaneous plasmacytosis is the invasion of the skin by plasma cells as a primary event, unrelated to another disease. When internal organs are involved as well, the term systemic plasmacytosis is used. Plasma cells may be present in the skin as a secondary event in relation to diseases such as malignancies (cutaneous plasmacytoma, marginal zone B-cell lymphoma, follicle center B-cell lymphoma), systemic lupus erythematosus, scleroderma, infections (bacterial, fungal, mycobacterial, syphilis), plasma cell vulvitis, systemic plasmacytosis, nodular amyloidosis, and cutaneous Rosai–Dorfman disease [Indian J Dermatol 2016;61:213-5].
Cutaneous lesions are characterized by disseminated reddish-brown macules and plaques distributed mainly on the trunk. One patient had multiple lesions of the breasts and groin, mimicking hidradenitis suppurativa.
A 46-year-old woman presented with asymptomatic, multiple, reddish-brown lesions in axillae, mammary area, lower abdomen, perineum, and upper inner thighs for 2 years. They started as small pea-sized lesions with a gradual progression in size and number. Indian J Dermatol 2016;61:213-5
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