By Gary M. White, MD

Cutaneous collagenous vasculopathy (CCV) is a rare disorder in which the patient develops diffuse telangiectasias. Positive PAS staining of hyaline material in the thickened cutaneous vessel walls is diagnostic.


Patients develop diffuse telangiectasias that often start on the legs and progress upward. There is no abnormal bleeding nor mucosal involvement. Most patients are middle-aged to older adults. A biopsy shows marked hyaline material in the thickened vessel walls. The hyaline material is derived from type IV collagen.

Differential Diagnosis

It must be differentiated from generalized essential telangiectasia by its histologic findings. Patients with CCV do not have mucosal involvement, family members with a similar condition, nor abnormal bleeding in contrast to patients with hereditary hemorrhagic telangiectasia.


No treatment is needed. A few patients have complained of pain in some areas but most are asymptomatic. Laser therapy has had some success and may be helpful. One patient failed to respond to traditional sclerotherapy [Cutaneous Collagenous Vasculopathy Brady et al J Clin Aesthet Dermatol 2015;8(11);49-52].


Cutaneous Collagenous Vasculopathy Brady et al J Clin Aesthet Dermatol 2015;8(11);49-52

Images in Clinical Medicine Dong-Lai Ma, M.D., Ph.D., and Sergio Vano-Galvan, M.D., Ph.D N Engl J Med 2015; 373:e14

Diffuse telangiectasias in a 51-year-old woman. JAAD November 2010 Volume 63, Issue 5, Pages 882–885


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