CUSHING'S DISEASE/CUSHING'S SYNDROME

By Gary M. White, MD


Cushing disease is caused by excessive secretion of cotricotropin by adenomas of the anterior pituitary gland. Excessive glucocorticoids--endogenous or exogenous--may cause enlargement of the cheeks (moon facies) and a buffalo hump secondary to deposition of fat. The extremities in contrast remain slender and the skin is atrophic and fragile. Corticotropin dependent disease includes Cushing's disease. Corticotropin-independent excess cortisol production by the adrenals may occur unilaterally (e.g. adenoma or carcinoma) or bilaterally (e.g. bilateral nodular adrenocortical hyperplasia).

Clinical

Typical features include weight gain, centripetal obesity, moon facies, proximal myopathy, psychiatric disturbances and a variety of skin manifestations which include:Violaceous skin stria, acne, hirsutism, acanthosis nigricans, superficial fungal infections (particularly tinea versicolor), hyperpigmentation, and skin thinning with easy bruisability.

RegionalDerm

Homepage | FAQs | Use of Images | Contact Dr. White


It is not the intention of RegionalDerm.com to provide specific medical advice, diagnosis or treatment. RegionalDerm.com only intends to provide users with information regarding various medical conditions for educational purposes and will not provide specific medical advice. Information on RegionalDerm.com is not intended as a substitute for seeking medical treatment and you should always seek the advice of a qualified healthcare provider for diagnosis and for answers to your individual questions. Information contained on RegionalDerm.com should never cause you to disregard professional medical advice or delay seeking treatment. If you live in the United States and believe you are having a medical emergency call 911 immediately.