By Gary M. White, MD

Cronkhite-Canada Syndrome (CCS) combines changes of the nails with skin pigmentation.


Diffuse hyperpigmentation, alopecia, and dystrophic nails all occur in Cronkhite-Canada syndrome. Hamartomatous polyps also occur although malignant change has been seen, primarily of the colon. Gastrointestinal symptoms include diarrhea, weight loss, abdominal pain, hemorrhage, intussusception, and perforation. The age of onset is approximately 60 years.

Patients are usually older men who develop lentigo-like macules on the face, palms, and extremities. The nail plate separates proximally and eventually sheds. The proximal nail fold may be soft and spongy and the nail bed boggy.


Spontaneous remission has been reported following aggressive nutritional support.


World Journal of Gastroenterology

Nail dystrophy involving associated with patchy hyperpigmentation, and severe hair loss. JAAD July 2010 Volume 63, Issue 1, Pages 172–174


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