By Gary M. White, MD
The CREST syndrome is a subgroup of systemic scleroderma. Sclerodactyly or induration and sclerosis of the skin of the fingers occurs. The skin is smooth and shiny, and the fingers tapered. Anticentromere antibodies are most characteristic of CREST but may also be found in systemic scleroderma patients.
- Therapy with the drug teriparatide may worsen preexisting calcinosis cutis [BJD 2016;175;1049].
- Calcinosis cutis
- Raynaud's phenomenon
- Esophageal dysfunction
The telangiectatic matting may be treated with laser. The calcinosis cutis may be treated effectively with diltiazem 240-480 mg/day [Arth Rheum 1995;38;1646] or by carbon dioxide laser [BJD 1996;135;302].
Treatment of Digital Ulcers
Raynaud's phenomenon in a patient with CREST syndrome.
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