COLD AGGLUTININ DISEASE

By Gary M. White, MD


Cold agglutinin disease is a rare form of autoimmune hemolytic anemia in which exposure to cold triggers thrombi formation.

Clinical

The ears and other acral sites become red and inflamed upon exposure to the cold.

Treatment

Cold avoidance is key. Systemic steroids have been used as have cytotoxic agents, plasmapheresis and rituximab.

References

Red, inflamed ears after a day exposed to the cold on a boat. JAMA Derm 2015;151;785.

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