By Gary M. White, MD
Cobb syndrome is the presence of a spinal arteriovenous malformation and a vascular skin lesion, e.g. port wine stain, affecting the corresponding dermatome.
- aka Cutaneomeningospinal angiomatosis
- Also, the term, spinal arteriovenous metameric syndrome, has been proposed [Eur J Radiol. 2003 Jun; 46(3):221-32].
- It is most common on the lower spine.
- Some suggest this to be a simple extension of the same process of venous dysplasia noted in the Sturge-Weber syndrome, but affecting the spinal, in lieu of cortical, veins.
Cutaneous lesions that have been reported include angiomas, angiokeratomas, angiolipomas, and lymphangioma circumscriptum.
The intraspinal lesions are usually AVMs and rarely angiomas. Neurologic symptoms develop most commonly in late childhood, but may occur at any age. They may present with sudden onset of weakness with rapid progression, monoparesis or sudden-onset paraplegia or quadriplegia. Bladder and bowel involvement is common but tends to occur late.
Patient with both the Sturge-Weber and the Cobb syndrome. The port-wine stain over the spinal canal corresponds to the Cobb syndrome.Trans Am Ophthalmol Soc. 2013 Sep; 111: 180–215
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