By Gary M. White, MD

Circumscribed palmar hypokeratosis

Circumscribed palmar hypokeratosis is a benign, usually solitary, lesion consisting of a sharply marginated thinning of the keratin. It is most common in middle-aged or older women.


Clinically, one sees a solitary red area of depressed skin. The edge well-defined and often white. (It may resemble porokeratosis but a cornoid lamella is not seen histologically). The palms, soles, and occasionally the dorsum of a finger [J Dermatol 2015;42:754] are affected. Biopsy shows the lesional skin to have an abrupt well-defined loss of the corneal layer. The underlying dermis shows a mild superficial perivascular infiltrate.


An. Bras. Dermatol. vol.88 no.4 Rio de Janeiro July/Aug. 2013


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