By Gary M. White, MD

CHILD syndrome (Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects) is a rare, X-linked dominant disorder.


One half of the body is affected with an ichthyosiform or psoriasiform fixed, often linear lesions which stop abruptly at the midline. There is a predilection for the body folds which has been called "ptychotropism". Ipsilateral shortening of limbs, abnormalities of the hair and nails and ipsilateral visceral abnormalities are characteristic. Punctate calcifications may be seen on X-ray and resolve after infancy. Some of these patients may have a disorder of peroxisomes.

A strawberry like growth at the end of a phalanx is pathognomonic.



Topical application of 2% ketaoncazole in oil was convincingly effective in one 15-year-old girl [Acta Dermato-Venereologica 2015;95;91-2].

Topical 2% lovastatin and 2% cholesterol cleared the skin in one case by blocking the pathway to prevent buildup and then give cholesterol to replace what the patient can't make [Biochim Biophys Acta. 2013 Sep 20. pii: S1388-1981].

A 10-year-old girl improved significantly with topical simvastatin and cholesterol ointment--see below [Pediatric Dermatology Vol. 32 No. 4 e145–e147, 2015].


CHILD syndrome with thrombocytosis and congenital dislocation of hip: A case report from India. Dermatology Online Journal 16(8)

J Am Acad Dermatology Volume 63, Issue 1, Pages 1–22, July 2010

Before and after treatment with topical application of 2% ketaoncazole in oil. [Acta Dermato-Venereologica 2015;95;91-2]

Before and after treatment w with topical simvastatin and cholesterol ointment. Pediatric Dermatology Vol. 32 No. 4 e145–e147, 2015

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