By Gary M. White, MD

Bullous Drug Eruption Bullous erythema multiforme. Courtesy Michael O. Murphy, MD

A bullous drug eruption is a drug eruption in which bulla form. This condition may be considered identical or very similar to bullous erythema multiforme. Many drugs may be implicated. Even prednisone [PD 1999;16;146] has caused a bullous drug eruption. There may be a spectrum here with overlap cases involving the conditions below.


Discontinuation of the drug is paramount. Oral steroids may be given. See Stevens Johnson Syndrome or Toxic epidermal necrolysis for widespread bullous involvement.


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