By Gary M. White, MD
Patients with melanoma can develop erythematous eruptions at the site of, or at a distance from, their primary melanocytic lesion; this is termed “Brenner sign.”
An erythematous rash adjacent to and in the general vicinity of the melanoma, with no distinguishable borders is characteristic. It is most common on the face.
A 41-year-old man presented with a rapidly growing subcutaneous supraclavicular mass with an overlying erythematous patch, which extended to the anterior chest wall. CT scan revealed a 5.0-cm, well-circumscribed solid mass. Fine needle aspiration and core biopsy showed metastatic signet ring cell melanoma. JAAD August 2011;65;444–446.
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