By Gary M. White, MD

Patients with melanoma can develop erythematous eruptions at the site of, or at a distance from, their primary melanocytic lesion; this is termed “Brenner sign.”


An erythematous rash adjacent to and in the general vicinity of the melanoma, with no distinguishable borders is characteristic. It is most common on the face.


A 41-year-old man presented with a rapidly growing subcutaneous supraclavicular mass with an overlying erythematous patch, which extended to the anterior chest wall. CT scan revealed a 5.0-cm, well-circumscribed solid mass. Fine needle aspiration and core biopsy showed metastatic signet ring cell melanoma. JAAD August 2011;65;444–446.


Homepage | FAQs | Use of Images | Contact Dr. White

It is not the intention of to provide specific medical advice, diagnosis or treatment. only intends to provide users with information regarding various medical conditions for educational purposes and will not provide specific medical advice. Information on is not intended as a substitute for seeking medical treatment and you should always seek the advice of a qualified healthcare provider for diagnosis and for answers to your individual questions. Information contained on should never cause you to disregard professional medical advice or delay seeking treatment. If you live in the United States and believe you are having a medical emergency call 911 immediately.