By Gary M. White, MD
Blepharochalasis refers to repeated episodes of eyelid edema leading to excessive laxity and wrinkling of the eyelids. A greatly diminished amount of dermal elastic fibers may be seen in advanced lesions. Immunofluorescence has shown IgA binding to dermal elastic fibers [BJD 1996;135;791]. It may occur as part of Ascher syndrome or generalized cutis laxa.
Ascher syndrome is characterized by bilateral blepharochalasis, double upper lip, and sometimes nontoxic goiter.
The disease usually begins in childhood with either unilateral or bilateral attacks of periorbital swelling. They last 2-3 days. Later, wrinkling develops. Thyroid studies should be performed to exclude non-toxic goiter as part of Ascher syndrome.
Blepharoplasty may be done. It has been recommended that the surgical correction be done at least 1 year after the last episode.
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