By Gary M. White, MD

Bleomycin-Induced Flagellate Dermatitis

A flagellate dermatitis may occur anywhere from a few hours to 2 months after exposure to the bleomycin. Most reported cases occurred after IM or IV administration but there has been at least one case after intralesional bleomycin treatment of verruca [Arch Dermatol. 2003;139:337-339].


Inflammatory, urticarial, or vesicular red lines followed by hyperpigmentation in a patient on bleomycin is characteristic.

Differential Diagnosis

See flagellate dermatoses.


Most cases resolve when the bleomycin is stopped. Symptomatic relief with antipruritic agents, antihistamines, systemic steroids, or potent topical steroids may be tried during the inflammatory stage.

Additional Pictures

Bleomycin-Induced Flagellate Dermatitis

Courtesy Michael O. Murphy, MD
Bleomycin-Induced Flagellate Dermatitis


Bendamustine-Induced “Flagellate Dermatitis.” Dermatology Online Journal 18 (11)

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