BASOSQUAMOUS CELL CARCINOMA
By Gary M. White, MD
A large, 11 x 4 cm basosquamaous cell carcinoma on the chest.
The basosquamous carcinoma (BSC) is an aggressive epithelial neoplasm with features of both basal cell carcinoma and squamous cell carcinoma, with a tendency toward local recurrence and a propensity for lymph node and distant metastases.
- The incidence of metastasis is at least 5%.
- The aggressive biological behavior and clinical course distinguish basosquamous carcinoma from other forms of BCC [JAAD 2009;60:137-43.]
The clinical appearance is usually that of a BCC. Specifically, papules, nodules and plaques with crusting, bleeding and ulceration are typical. A rolled border may be seen.
Histologically, basaloid SCC and basoquamous cell carcinoma must be distinguished.
Mohs surgery is the treatment of choice. Published recurrence rates are 12% to 51% for surgical excision and 4% for Mohs micrographic surgery.
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