By Gary M. White, MD
The morpheaform BCC may take on a yellowish hue as shown here.
A morpheaform basal cell carcinoma is a BCC which histologically has a fibrotic or scar-like component. It is often more aggressive than the nodular BCC. The prior use of fluorouracil has been shown to predispose to the development of morpheaform BCC in elderly men with an OR of 2.49 [JAMADerm 2014;150;332]. Also patients whose first BCC was morpheaform and that developed a second BCC, the second BCC was 12 times more likely to be morpheaform compared with patients whose first BCC was not morpheaform.
The morpheaform BCC resembles the more common nodular BCC in many ways, although it may have a slightly more yellowish tinge.
Surgical excision is the indicated treatment. Mohs surgery is appropriate for lesions on the face. Therapies used for other histologic types of BCC, e.g. photodynamic therapy are not sufficiently effective for morpheaform BCC.
The histology may not be readily apparent clinically. This BCC had a morpheaform histology on biopsy.
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