By Gary M. White, MD

Bart's Syndrome

Bart's syndrome appears to be a minor subtype of dominantly inherited dystrophic epidermolysis bullosa. Patients are typically born with bilaterally symmetric localized absence of skin along the lower leg from the knee, down the shin, to the foot. It is thought that physical trauma in utero (e.g., rubbing of the legs together) is the reason for this area of the body to be preferentially affected.


Blistering at or shortly after birth is typical and affects the hands, legs, and feet. Scarring and milia formation may occur. Nails, especially toenails, are commonly absent at birth.


See epidermolysis bullosa.

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