By Gary M. White, MD

B-Cell Lymphoma of the Skin

When B-cell lymphoma involves the skin, it is usually secondary to systemic disease. Primary cutaneous B-cell lymphoma (PCBCL) may, however, start in the skin and when it does, the prognosis tends to be good. Clinically, PCBCL tends to present with one or several nodules on the head and neck or trunk.


Erythematous papules and nodules are characteristic. Rarely, B-cell lymphoma may mimic cutaneous T-cell lymphoma clinically and histologically [JAAD 1999;41;271].


Therapy should be carried out by an oncologist. Indolent primary cutaneous B-cell lymphomas may be effectively treated with subcutaneous interferon-alfa [JAAD April 2014].

Additional Pictures

A solitary lesion on the back. Courtesy Marc Rubenzik, MD
B-Cell Lymphoma of the Skin

MALT (mucosa-associated lymphoid tissue) lymphoma
B-Cell Lymphoma of the Skin

B-cell lymphoma. Solitary nodule on the thigh of an elderly woman with B-cell lymphoma "in remission."
B-Cell Lymphoma of the Skin B-Cell Lymphoma of the Skin


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