By Gary M. White, MD

Aquagenic Wrinkling of the Palms

Aquagenic wrinkling of the palms (AWP) is a rare condition where the skin of the palms wrinkles after brief immersion in water. The normal person's palmar skin wrinkles when submersed in water after 11-12 minutes. The patient with AWP develops wrinkling after just 2-3 minutes. AWP is associated with cystic fibrosis (CF). One study found that of CF patients, 41% had AWP. Aquagenic wrinkling has been reported on the soles and, in one case report, on the dorsal fingers.

Other names that have been used include transient reactive papulotranslucent acrokeratoderma, aquagenic syringeal acrokeratoderma, and aquagenic palmoplantar keratoderma.

Should You Screen for Cystic Fibrosis?

Some would argue that you should screen for CF as otherwise normal patients with AWP may be CF carriers. Others would argue that you should not as 1/25 of Caucasians in the normal population are CF carriers, and the overwhelming majority lead healthy lives and have healthy children.


No treatment is needed.

Additional Pictures

Aquagenic Wrinkling of the Palms


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