By Gary M. White, MD

Note: This is a summary only. Please consult the latest information when prescribing.

Indications for Adults 18 Years of Age or Older

Mechanism of Action

Inhibits PDE4 but full mechanism of action is not fully understood.

Efficacy in Psoriasis

Trade Name in US



Warnings and Precautions

Depression occurred in 1.3% of patients on Otezla compared with 0.4% of patients on placebo.

Adverse Reactions (Otezla %, placebo %)

Pregnancy Category


Atopic Dermatitis

There is some interest and some data that apremilast can improve atopic dermatitis. [Arch Dermatol. 2012 Aug;148(8):890-7].

Multiple Lentigines

Multiple lentigines have occurred in patients with psoriasis treated with apremilast (in this report, a total of 5) [JAAD 2016;75;1251]. All cases occurred in the first four months of treatment only on psoriatic lesions that had regressed. None of the patients received phototherapy, and lentigines appeared in most cases in sun-protected areas. Lentigines were still present five years after their occurrence.


Homepage | FAQs | Use of Images | Contact Dr. White

It is not the intention of RegionalDerm.com to provide specific medical advice, diagnosis or treatment. RegionalDerm.com only intends to provide users with information regarding various medical conditions for educational purposes and will not provide specific medical advice. Information on RegionalDerm.com is not intended as a substitute for seeking medical treatment and you should always seek the advice of a qualified healthcare provider for diagnosis and for answers to your individual questions. Information contained on RegionalDerm.com should never cause you to disregard professional medical advice or delay seeking treatment. If you live in the United States and believe you are having a medical emergency call 911 immediately.