ANTI-P200 PEMPHIGOID

By Gary M. White, MD


Anti-p200 pemphigoid (APP), aka anti-laminin γ1 pemphigoid, is a rare autoimmune bullous dermatosis that closely resembles classic bullous pemphigoid, but has tense blisters with preference for the hands and feet.

Clinical

Almost all patients experience bulla and pruritus. Bulla are almost always found on the hands, with variable involvement of the arms, feet, and trunk.

Treatment

Treatment usually involves topical and systemic steroids initially. Azathioprine, dapsone, and doxycycline may also be given.

References

This article contains an excellent review on diagnosing APP and differentiating it from classic bullous pemphigoid, EBA, and mucous membrane pemphigoid. JAMA Derm 2016;152;897.

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