Anetoderma in simple terms is focal areas of inelastic or "wrinkled skin" caused by a loss of elastic tissue. In primary anetoderma, inflammation may or may not be clinically apparent prior to the wrinkling. In secondary anetoderma, an inflammatory skin condition (e.g., acne, syphilis, lupus erythematosus) precedes the anetoderma. Anetoderma has also been reported to occur over a pilomatricoma, cutaneous plasmacytoma, and benign cutaneous lymphoid hyperplasia. There is an anetoderma of prematurity wherein atrophic patches develop in extremely premature infants at the site of the placement of monitoring leads. Hereditary types have also been reported, with autosomal dominant, autosomal recessive, or undefined patterns. In these familial cases, the anetoderma may be an isolated sign, or associated with significant abnormalities (e.g., osteogenesis imperfecta, osteopetrosis, primary optic atrophy, exostoses, and brachydactyly [JAAD 1996;35;999]). There is a rare anetodermic primary cutaneous B-cell lymphoma [Arch Dermatol. 2010 Feb;146(2):175-82].


Well-defined, round, or oval areas of wrinkled skin appear in anetoderma. Alternatively, soft, compressible papules and nodules may occur.


In secondary anetoderma, the primary disease should be treated. The combination of 595-nm PDL and 1550-nm non-ablative fractionated laser has been reported helpful in anetoderma [J Cosmet Laser Ther. 2015 Jul 3:1-3]. The ablative 10,600-nm carbon dioxide fractional laser has also been tried [Dermatol Surg. 2012 Apr;38(4):677-9].

Additional Pictures

Anetoderma in a patient with lupus.



Anetoderma secondary to B-cell lymphoma. From Acta Derm Venereol 2015; 95: 499–500


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