By Gary M. White, MD
Anosacral amyloid is the occurrence of macular amyloid in the anosacral region.
- Within the differential diagnosis is simple thickening and lichenification of the skin. Indeed, one study found hyperkeratosis, acanthosis and follicular plugging histologically without amyloid deposition [J Dermatol. 2006;33:779-82].
Brown linear macules and papules radiating out from the anus in an older adult are characteristic of anosacral amyloid.
No treatment is needed. If there is dryness and irrigation, moisturization and/or a topical steroid may be given. See also macular amyloid for treatment.
Br J Dermatol. 2000 Dec;143(6):1266-9.
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