Two types of alopecia mucinosa (AM) are seen: a benign type and one associated with CTCL or Hodgkins lymphoma. As a generality, the benign type affects the head and neck, occurs in people under 30, and the lesions are either single or few. The histologic term often used is follicular mucinosis.
Flesh to erythematous colored, follicular papules which may coalesce into plaques most common on the face are characteristic. Alopecia may occur in the lesion.
Every effort should be made to exclude malignancy which occurs approximately 15-30% of the time. Treatments include topical, intralesional, and systemic corticosteroids. Topical and systemic psoralen plus ultraviolet A (PUVA) light therapy, topical nitrogen mustard, and radiation therapy have demonstrated some success. Minocycline 100 mg/day completely cleared a case of benign AM after one month. Other therapies have included UVA-1, antimalarials, dapsone, indomethacin, isotretinoin, and interferon alfa-2b.