By Gary M. White, MD
Note, this is a brief summary only. More complete information and recent studies should be consulted before prescribing alitretinoin.
Alitretinoin is a pan-agonist for retinoid receptors, binding both retinoic acid and retinoid X receptors.
- Topical alitretinoin is Panretin, FDA approved for Kaposi's sarcoma.
- Oral alitretinoin has been reported helpful in hand dermatitis, nail lichen planus, palmoplantar CTCL, Hailey-Hailey disease, hidradenitis suppurativa (teratogenic but shorter half life than acitretin [G Ital Dermatol Venereol. 2014]) and pityriasis rubra pilaris.
- Alitretinoin is absolutely contraindicated in pregnancy.
Panretin® gel should initially be applied two (2) times a day to cutaneous KS lesions.
Dosing recommendations in the UK for oral alitretinoin for hand dermatitis are to start at the 30 mg/day dose and decrease if side effects require it. (comes in 10 and 30 mg capsules in the UK as Toctino).
Most off label us of the oral form uses a dose of 30 mg/day.
Absolutely contraindicated in pregnancy.
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