By Gary M. White, MD

Note, this is a brief summary only. More complete information and recent studies should be consulted before prescribing alitretinoin.

Alitretinoin is a pan-agonist for retinoid receptors, binding both retinoic acid and retinoid X receptors.



PanretinĀ® gel should initially be applied two (2) times a day to cutaneous KS lesions.


Dosing recommendations in the UK for oral alitretinoin for hand dermatitis are to start at the 30 mg/day dose and decrease if side effects require it. (comes in 10 and 30 mg capsules in the UK as Toctino).

Most off label us of the oral form uses a dose of 30 mg/day.


Absolutely contraindicated in pregnancy.


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