By Gary M. White, MD

AESOP syndrome is the presence of an extensive violaceous skin patch overlying a solitary plasmacytoma of bone that is associated with regional lymphadenopathy.


A slowly enlarging erythematous to violaceous plaque or patch on the thorax is most typical. The increase in size may be slow or relatively rapid. Imaging shows a plasmacytoma of bone and regional lymphadenopathy.


Referral to a hematologist/oncologist is in order.


A 57-year-old presents with a six-month history of an expanding, violaceous plaque of the left flank. Initial biopsy and workup did not show any underlying abnormalities. Eighteen months later, however, MRI showed a mass within a rib as well as multiple enlarged intrathoracic regional lymph nodes. Great case illustrating how there may be a delay in the onset of all features of AESOP Syndrome. Adenopathy and extensive skin patch overlying a plasmacytoma (AESOP) syndrome Parker et al. Dermatology Online Journal 19 (2): 8

A similar phenomenon has been reported overlying a Ewing sarcoma-like malignant blue-cell tumor. A 53-year-old man was referred for a pruritic eruption on his central chest of 8 months' duration. He reported a sensation of bulging over his lower sternum. Exam showed a large red plaque covering most of the chest. The lesion resolved with treatment of the tumor. Arch Dermatol. 2012;148(12):1431-1432


Homepage | FAQs | Use of Images | Contact Dr. White

It is not the intention of to provide specific medical advice, diagnosis or treatment. only intends to provide users with information regarding various medical conditions for educational purposes and will not provide specific medical advice. Information on is not intended as a substitute for seeking medical treatment and you should always seek the advice of a qualified healthcare provider for diagnosis and for answers to your individual questions. Information contained on should never cause you to disregard professional medical advice or delay seeking treatment. If you live in the United States and believe you are having a medical emergency call 911 immediately.