AESOP SYNDROME

By Gary M. White, MD


AESOP syndrome is the presence of an extensive violaceous skin patch overlying a solitary plasmacytoma of bone that is associated with regional lymphadenopathy.

Clinical

A slowly enlarging erythematous to violaceous plaque or patch on the thorax is most typical. The increase in size may be slow or relatively rapid. Imaging shows a plasmacytoma of bone and regional lymphadenopathy.

Treatment

Referral to a hematologist/oncologist is in order.

References

A 57-year-old presents with a six-month history of an expanding, violaceous plaque of the left flank. Initial biopsy and workup did not show any underlying abnormalities. Eighteen months later, however, MRI showed a mass within a rib as well as multiple enlarged intrathoracic regional lymph nodes. Great case illustrating how there may be a delay in the onset of all features of AESOP Syndrome. Adenopathy and extensive skin patch overlying a plasmacytoma (AESOP) syndrome Parker et al. Dermatology Online Journal 19 (2): 8

A similar phenomenon has been reported overlying a Ewing sarcoma-like malignant blue-cell tumor. A 53-year-old man was referred for a pruritic eruption on his central chest of 8 months' duration. He reported a sensation of bulging over his lower sternum. Exam showed a large red plaque covering most of the chest. The lesion resolved with treatment of the tumor. Arch Dermatol. 2012;148(12):1431-1432

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