By Gary M. White, MD

Acrokeratosis verruciformis of Hopf (AKV) is a benign, dominantly inherited presence of keratotic papules on the dorsal hands and feet.

Acrokeratosis verruciformis of Hopf vs Darier Disease


Flesh-colored, hyperkeratotic papules on the dorsa of the hands and feet is characteristic. In some cases, they may be widespread, affecting the knees, elbows, forearms, or lower legs. Palmar pits and/or keratoses may be seen. Nail involvement may occur in the form of longitudinal splitting, striations, and subungual hyperkeratosis.

Acrokeratosis verruciformis of Hopf on the dorsal hands may look identical to stucco keratoses. e.g. Ann Dermatol. 2011 Sep; 23(Suppl 1): S61–S63.


No treatment is needed. Reported successful interventions include topical retinoids, cryotherapy, and carbon dioxide laser ablation. Oral retinoids have also been variably beneficial, e.g. acitretin.


A 34-year-old woman presented with multiple asymptomatic discrete hyperpigmented and hypopigmented lesions over scalp, face, neck, trunk, and both limbs for 2 years. Indian J Dermatol 2016;61:237

Acrokeratosis verruciformis of Hopf in family. Indian Dermatol Online J 2014;5, Suppl S1:17-9


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