ACROKERATOSIS VERRUCIFORMIS OF HOPF

By Gary M. White, MD


Acrokeratosis verruciformis of Hopf (AKV) is a benign, dominantly inherited presence of keratotic papules on the dorsal hands and feet.

Acrokeratosis verruciformis of Hopf vs Darier Disease

Clinical

Flesh-colored, hyperkeratotic papules on the dorsa of the hands and feet is characteristic. In some cases, they may be widespread, affecting the knees, elbows, forearms, or lower legs. Palmar pits and/or keratoses may be seen. Nail involvement may occur in the form of longitudinal splitting, striations, and subungual hyperkeratosis.

Acrokeratosis verruciformis of Hopf on the dorsal hands may look identical to stucco keratoses. e.g. Ann Dermatol. 2011 Sep; 23(Suppl 1): S61–S63.

Treatment

No treatment is needed. Reported successful interventions include topical retinoids, cryotherapy, and carbon dioxide laser ablation. Oral retinoids have also been variably beneficial, e.g. acitretin.

References

A 34-year-old woman presented with multiple asymptomatic discrete hyperpigmented and hypopigmented lesions over scalp, face, neck, trunk, and both limbs for 2 years. Indian J Dermatol 2016;61:237

Acrokeratosis verruciformis of Hopf in family. Indian Dermatol Online J 2014;5, Suppl S1:17-9

RegionalDerm

Home | FAQs | Use of Images | Privacy Policy | Contact


It is not the intention of RegionalDerm.com to provide specific medical advice, diagnosis or treatment. RegionalDerm.com only intends to provide users with information regarding various medical conditions for educational purposes and will not provide specific medical advice. Information on RegionalDerm.com is not intended as a substitute for seeking medical treatment and you should always seek the advice of a qualified healthcare provider for diagnosis and for answers to your individual questions. Information contained on RegionalDerm.com should never cause you to disregard professional medical advice or delay seeking treatment. If you live in the United States and believe you are having a medical emergency call 911 immediately.