By Gary M. White, MD
Acrokeratosis paraneoplastica (Bazek) is a paraneoplastic syndrome characterized by a papulosquamous eruption of the ears, nose, fingers, and toes.
- AKA Bazex syndrome
- Most common neoplastic association is with squamous cell carcinoma (SCC) of the aerodigestive tract
- Most patients are men over 40 years of age
Several stages have been described:
- Erythematous and keratotic lesions of the ears, nose, fingers, and toes with nail dystrophy
- Hyperkeratotic lesions then develop on the palms and soles
- Erythematous and keratotic lesions on the trunk and extremities
SCC of the head, neck, and esophagus are most common, but neoplasms of the breast, prostate, and bladder have been described. The cutaneous lesions usually develop before the tumor is diagnosed, in one study 11 months on average before the discovery of the cancer.
JEADV 2017; 31;1111
Dermatology Online Journal 10(1)
Actas Dermosifiliogr. 2013;104:285-98
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